› 6vx9

Electron Microscopy
2.17Å resolution

bestrophin-2 Ca2+- unbound state 1 (EGTA only)

Released:
DOI: 10.2210/pdb6vx9/pdb
PDB entry 6vx9 coloured by chain, front view.
PDB entry 6vx9 coloured by chain, side view.
PDB entry 6vx9 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural and functional characterization of the bestrophin-2 anion channel.
Owji AP, Zhao Q, Ji C, Kittredge A, Hopiavuori A, Fu Z, Ward N, Clarke OB, Shen Y, Zhang Y, Hendrickson WA, Yang T
OpenAccess logo Nat Struct Mol Biol 27 382-391 (2020)
PMID: 32251414
Related structures: EMD-21434

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122746 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bestrophin-2 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 410 amino acids
Theoretical weight: 47.42 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: E1BF86 (Residues: 1-410; Coverage: 80%)
Gene name: BEST2
Sequence domains: Bestrophin, RFP-TM, chloride channel

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.17Å
Relevant EMDB volumes: EMD-21434
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Structure and Function of the Bestrophin family of calcium-activated chloride channels.
Owji et al. (2021)
2 more

1 mention without citation

Structural and functional characterization of the bestrophin-2 anion channel.
Owji et al. (2020)