› 6vxo

Electron Microscopy
3.5Å resolution

NaChBac-Nav1.7VSDII chimera in nanodisc

Released:
DOI: 10.2210/pdb6vxo/pdb
PDB entry 6vxo coloured by chain, front view.
PDB entry 6vxo coloured by chain, side view.
PDB entry 6vxo coloured by chain, top view.
Source organisms:
Primary publication:
Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc.
Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N
Proc Natl Acad Sci U S A 117 14187-14193 (2020)
PMID: 32513729
Related structures: EMD-21446

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172432 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein; Sodium channel protein type 9 subunit alpha Chains: A, C, D, E
Molecule details ›
Chains: A, C, D, E
Length: 277 amino acids
Theoretical weight: 31.9 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q9KCR8 (Residues: 1-97, 114-274; Coverage: 94%)
  • Canonical: Q15858 (Residues: 817-835; Coverage: 1%)
Gene names: BH1501, NENA, SCN9A
Sequence domains: Ion transport protein

Ligands and Environments

1 bound ligand:
Ligand POV 12 x POV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-21446
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Druggability of Voltage-Gated Sodium Channels-Exploring Old and New Drug Receptor Sites.
Wisedchaisri et al. (2022)
4 more

1 mention without citation

Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc.
Gao et al. (2020)