› 6w2y

Electron Microscopy
3.2Å resolution

CryoEM Structure of GABAB1b Homodimer

Released:
DOI: 10.2210/pdb6w2y/pdb
PDB entry 6w2y coloured by chain, front view.
PDB entry 6w2y coloured by chain, side view.
PDB entry 6w2y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of metabotropic GABAB receptor.
Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G
Nature 584 310-314 (2020)
PMID: 32580208
Related structures: EMD-21534

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Gamma-aminobutyric acid type B receptor subunit 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 829 amino acids
Theoretical weight: 94.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBS5 (Residues: 153-961; Coverage: 85%)
Gene names: GABBR1, GPRC3A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 4 x NAG
Ligand MG 2 x MG
Ligand L9Q 2 x L9Q
Ligand SGG 2 x SGG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-21534
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors.
Cerne et al. (2022)
16 more

6 mentions without citation

New insights into GPCR coupling and dimerisation from cryo-EM structures.
Gusach et al. (2023)
5 more