› 6w3c

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130962 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase/endoribonuclease IRE1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 434 amino acids
Theoretical weight: 49.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75460 (Residues: 547-977; Coverage: 45%)
Gene names: ERN1, IRE1
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 12 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21
Unit cell:
a: 47.492Å b: 158.664Å c: 155.944Å
α: 90° β: 91.01° γ: 90°
R-values:
R R work R free
0.208 0.206 0.248
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Pharmacological targeting of endoplasmic reticulum stress in disease.
Marciniak et al. (2022)
4 more

2 mentions without citation

Dual RNase activity of IRE1 as a target for anticancer therapies.
Bartoszewska et al. (2023)
1 more