› 6wad

X-ray diffraction
2.45Å resolution

Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with MT2739 inhibitor

Released:
DOI: 10.2210/pdb6wad/pdb
PDB entry 6wad coloured by chain, front view.
PDB entry 6wad coloured by chain, side view.
PDB entry 6wad coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Halabelian L, Zeng H, Dong A, Schapira M, De Freitas RF, Hutchinson A, Seitova A, Bountra C, Edwards AM, Arrowsmith CH, Brown PJ, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein arginine N-methyltransferase 6 Chain: A
Molecule details ›
Chain: A
Length: 376 amino acids
Theoretical weight: 42.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96LA8 (Residues: 1-375; Coverage: 100%)
Gene names: HRMT1L6, PRMT6
Sequence domains: Methyltransferase domain

Ligands and Environments

2 bound ligands:
Ligand SAH 1 x SAH
Ligand TQ7 1 x TQ7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: I41
Unit cell:
a: 94.068Å b: 94.068Å c: 109.242Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.226
Expression system: Spodoptera frugiperda

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