› 6wc9

Electron Microscopy
2.64Å resolution

Human open state TMEM175 in KCl

Released:
DOI: 10.2210/pdb6wc9/pdb
PDB entry 6wc9 coloured by chain, front view.
PDB entry 6wc9 coloured by chain, side view.
PDB entry 6wc9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175.
Oh S, Paknejad N, Hite RK
Elife 9 (2020)
PMID: 32228865
Related structures: EMD-21603

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endosomal/lysosomal proton channel TMEM175 Chains: A, B
Molecule details ›
Chains: A, B
Length: 504 amino acids
Theoretical weight: 55.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSA9 (Residues: 1-504; Coverage: 100%)
Gene name: TMEM175
Sequence domains: Endosomal/lysosomal potassium channel TMEM175

Ligands and Environments

1 bound ligand:
Ligand K 7 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.64Å
Relevant EMDB volumes: EMD-21603
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Lysosomal Potassium Channels.
Huang et al. (2023)
1 more

9 mentions without citation

Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease.
Tang et al. (2023)
8 more