Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- SH2 domain
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- mRNA cap 0/1 methyltransferase
- SH2 domain superfamily
- STAT transcription factor, protein interaction
- STAT transcription factor, N-terminal domain superfamily
- RNA-directed RNA polymerase, thumb subdomain, flavivirus
- RNA-directed RNA polymerase, catalytic domain
12 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156585 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Signal transducer and activator of transcription 2
Molecule details ›
Chain: A
Length: 851 amino acids
Theoretical weight: 98.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
Sequence domains:
Length: 851 amino acids
Theoretical weight: 98.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
- Canonical:
P52630 (Residues: 1-851; Coverage: 100%)
Sequence domains:
RNA-directed RNA polymerase NS5
Molecule details ›
Chain: B
Length: 903 amino acids
Theoretical weight: 103.12 KDa
Source organism: Zika virus
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
Length: 903 amino acids
Theoretical weight: 103.12 KDa
Source organism: Zika virus
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
- Canonical: Q32ZE1 (Residues: 2517-3419; Coverage: 26%)
