› 6wjh

X-ray diffraction
2.19Å resolution

Crystal structure of MAGE-A11 bound to the PCF11 degron

Released:
DOI: 10.2210/pdb6wjh/pdb
PDB entry 6wjh coloured by chain, front view.
PDB entry 6wjh coloured by chain, side view.
PDB entry 6wjh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
Yang SW, Huang X, Lin W, Min J, Miller DJ, Mayasundari A, Rodrigues P, Griffith EC, Gee CT, Li L, Li W, Lee RE, Rankovic Z, Chen T, Potts PR
Nat Commun 11 4931 (2020)
PMID: 33004795

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melanoma-associated antigen 11; Pre-mRNA cleavage complex 2 protein Pcf11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 243 amino acids
Theoretical weight: 27.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94913 (Residues: 677-701; Coverage: 2%)
  • Canonical: P43364 (Residues: 218-429; Coverage: 49%)
Gene names: KIAA0824, MAGE11, MAGEA11, PCF11
Sequence domains: MAGE homology domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P1
Unit cell:
a: 55.493Å b: 78.195Å c: 72.911Å
α: 77.44° β: 77.34° γ: 89.59°
R-values:
R R work R free
0.207 0.205 0.246
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation.
Bond et al. (2021)
4 more

3 mentions without citation

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
Yang et al. (2020)
2 more