› 6wmf

X-ray diffraction
2.6Å resolution

Human Sun2-KASH5 complex

Released:
DOI: 10.2210/pdb6wmf/pdb
PDB entry 6wmf coloured by chain, front view.
PDB entry 6wmf coloured by chain, side view.
PDB entry 6wmf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
Cruz VE, Esra Demircioglu F, Schwartz TU
J Mol Biol 432 6028-6041 (2020)
PMID: 33058875

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185418 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SUN domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 22.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UH99 (Residues: 522-717; Coverage: 27%)
Gene names: FRIGG, KIAA0668, RAB5IP, SUN2, UNC84B
Sequence domains: Sad1 / UNC-like C-terminal
Protein KASH5 Chain: B
Molecule details ›
Chain: B
Length: 27 amino acids
Theoretical weight: 2.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N6L0 (Residues: 542-562; Coverage: 4%)
Gene names: CCDC155, KASH5

Ligands and Environments

1 bound ligand:
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: R32
Unit cell:
a: 78.435Å b: 78.435Å c: 249.441Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.221 0.286
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Mechanics and functional consequences of nuclear deformations.
Kalukula et al. (2022)
2 more