› 6wnl

X-ray diffraction
2.37Å resolution

human Artemis/SNM1C catalytic domain, crystal form 2

Released:
DOI: 10.2210/pdb6wnl/pdb
PDB entry 6wnl coloured by chain, front view.
PDB entry 6wnl coloured by chain, side view.
PDB entry 6wnl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features.
Karim MF, Liu S, Laciak AR, Volk L, Koszelak-Rosenblum M, Lieber MR, Wu M, Curtis R, Huang NN, Carr G, Zhu G
J Biol Chem 295 12368-12377 (2020)
PMID: 32576658

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein artemis Chains: A, B
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 43.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96SD1 (Residues: 2-368; Coverage: 53%)
Gene names: ARTEMIS, ASCID, DCLRE1C, SCIDA, SNM1C
Sequence domains: DNA repair metallo-beta-lactamase

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 69.209Å b: 105.675Å c: 116.037Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.221 0.28
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.
Bahr et al. (2021)
7 more

3 mentions without citation

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Liu et al. (2022)
2 more