› 6wnx

X-ray diffraction
2.5Å resolution

FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide

Released:
DOI: 10.2210/pdb6wnx/pdb
PDB entry 6wnx coloured by chain, front view.
PDB entry 6wnx coloured by chain, side view.
PDB entry 6wnx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ivanochko D, Edwards AM, Bountra C, Arrowsmith CH, Boettcher J, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-152832 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
F-box/WD repeat-containing protein 11 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 429 amino acids
Theoretical weight: 49.23 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9UKB1 (Residues: 114-542; Coverage: 79%)
Gene names: BTRCP2, FBW1B, FBXW11, FBXW1B, KIAA0696
Sequence domains:
S-phase kinase-associated protein 1 Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 145 amino acids
Theoretical weight: 16.59 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63208 (Residues: 1-163; Coverage: 89%)
Gene names: EMC19, OCP2, SKP1, SKP1A, TCEB1L
Sequence domains:
Catenin beta-1 Chains: C, F, I
Molecule details ›
Chains: C, F, I
Length: 9 amino acids
Theoretical weight: 1.02 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P35222 (Residues: 31-39; Coverage: 1%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286

Ligands and Environments

2 bound ligands:
Ligand GOL 6 x GOL
Ligand NA 2 x NA
1 modified residue:
Ligand SEP 6 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 119.732Å b: 81.866Å c: 133.198Å
α: 90° β: 92.92° γ: 90°
R-values:
R R work R free
0.208 0.206 0.251
Expression systems:
  • Trichoplusia ni
  • Not provided

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