› 6wo0

X-ray diffraction
1.97Å resolution

human Artemis/SNM1C catalytic domain, crystal form 1

Released:
DOI: 10.2210/pdb6wo0/pdb
PDB entry 6wo0 coloured by chain, front view.
PDB entry 6wo0 coloured by chain, side view.
PDB entry 6wo0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features.
Karim MF, Liu S, Laciak AR, Volk L, Koszelak-Rosenblum M, Lieber MR, Wu M, Curtis R, Huang NN, Carr G, Zhu G
J Biol Chem 295 12368-12377 (2020)
PMID: 32576658

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein artemis Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 43.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96SD1 (Residues: 2-368; Coverage: 53%)
Gene names: ARTEMIS, ASCID, DCLRE1C, SCIDA, SNM1C
Sequence domains: DNA repair metallo-beta-lactamase

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21212
Unit cell:
a: 72.69Å b: 111.01Å c: 55.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.27
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.
Bahr et al. (2021)
5 more

7 mentions without citation

Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks.
Watanabe et al. (2022)
6 more