Function and Biology Details
Reaction catalysed:
Cleavage of the -Glu-|-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-171730 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Tubulin alpha-1A chain
Molecule details ›
Chains: A, E
Length: 451 amino acids
Theoretical weight: 50.19 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 451 amino acids
Theoretical weight: 50.19 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q71U36 (Residues: 1-451; Coverage: 100%)
Sequence domains:
Tubulin beta-3 chain
Molecule details ›
Chains: B, F
Length: 450 amino acids
Theoretical weight: 50.48 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 450 amino acids
Theoretical weight: 50.48 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: Q13509 (Residues: 1-450; Coverage: 100%)
Sequence domains:
Tubulinyl-Tyr carboxypeptidase 1
Small vasohibin-binding protein
Molecule details ›
Chains: D, H
Length: 66 amino acids
Theoretical weight: 7.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Coiled-coil domain-containing protein 23
Length: 66 amino acids
Theoretical weight: 7.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q8N300 (Residues: 1-66; Coverage: 100%)
Sequence domains: Coiled-coil domain-containing protein 23
