› 6wvl

Electron Microscopy
3.2Å resolution

Low curvature lateral interaction within a 13-protofilament, Taxol stabilized microtubule

Released:
DOI: 10.2210/pdb6wvl/pdb
PDB entry 6wvl coloured by chain, front view.
PDB entry 6wvl coloured by chain, side view.
PDB entry 6wvl coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Dynamic and asymmetric fluctuations in the microtubule wall captured by high-resolution cryoelectron microscopy.
Debs GE, Cha M, Liu X, Huehn AR, Sindelar CV
Proc Natl Acad Sci U S A 117 16976-16984 (2020)
PMID: 32636254
Related structures: EMD-21922

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160593 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tubulin alpha-1B chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 451 amino acids
Theoretical weight: 50.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-451; Coverage: 100%)
Sequence domains:
Tubulin beta-2B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 445 amino acids
Theoretical weight: 49.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-445; Coverage: 100%)
Gene name: TUBB2B
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand GTP 2 x GTP
Ligand MG 2 x MG
Ligand GDP 2 x GDP
Ligand TA1 2 x TA1
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-21922

Quick links

Citations

5 review citations

Molecular mechanisms underlying microtubule growth dynamics.
Cleary et al. (2021)
4 more

1 mention without citation

Dynamic and asymmetric fluctuations in the microtubule wall captured by high-resolution cryoelectron microscopy.
Debs et al. (2020)