› 6ww5

Electron Microscopy
3.15Å resolution

Structure of VcINDY-Na-Fab84 in nanodisc

Released:
DOI: 10.2210/pdb6ww5/pdb
PDB entry 6ww5 coloured by chain, front view.
PDB entry 6ww5 coloured by chain, side view.
PDB entry 6ww5 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Sauer DB, Trebesch N, Marden JJ, Cocco N, Song J, Koide A, Koide S, Tajkhorshid E, Wang DN
Elife 9 (2020)
PMID: 32869741
Related structures: EMD-21928

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212775 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Citrate transporter-like domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 449 amino acids
Theoretical weight: 48.16 KDa
Source organism: Vibrio cholerae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9KNE0 (Residues: 14-462; Coverage: 97%)
Gene name: VC_A0025
Sequence domains: Citrate transporter
Fab84 Heavy Chain Chains: C, E
Molecule details ›
Chains: C, E
Length: 261 amino acids
Theoretical weight: 28.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Fab84 Light Chain Chains: D, F
Molecule details ›
Chains: D, F
Length: 238 amino acids
Theoretical weight: 25.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand 6PE 2 x 6PE
Ligand HEX 2 x HEX
Ligand OCT 2 x OCT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.15Å
Relevant EMDB volumes: EMD-21928
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Drosophila INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions.
Jaramillo-Martinez et al. (2021)
1 more

3 mentions without citation

Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Sauer et al. (2020)
2 more