› 6wx7

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155730 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 510 amino acids
Theoretical weight: 55.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 70-529; Coverage: 87%)
Gene names: Kpna2, Rch1
Sequence domains:
Transcription factor SOX-2 Chain: B
Molecule details ›
Chain: B
Length: 90 amino acids
Theoretical weight: 11.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48431 (Residues: 39-127; Coverage: 28%)
Gene name: SOX2
Sequence domains: HMG (high mobility group) box

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 78.07Å b: 91.291Å c: 97.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.227
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Karyopherin-mediated nucleocytoplasmic transport.
Wing et al. (2022)
2 more