› 6x17

Electron Microscopy
3.66Å resolution

Outward-facing state of the glutamate transporter homologue GltPh in complex with TBOA

Released:
DOI: 10.2210/pdb6x17/pdb
PDB entry 6x17 coloured by chain, front view.
PDB entry 6x17 coloured by chain, side view.
PDB entry 6x17 coloured by chain, top view.
Source organism: Pyrococcus horikoshii
Primary publication:
Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters.
Wang X, Boudker O
Elife 9 (2020)
PMID: 33155546
Related structures: EMD-21991

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate transporter homolog Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 422 amino acids
Theoretical weight: 44.67 KDa
Source organism: Pyrococcus horikoshii
Expression system: Escherichia coli
UniProt:
  • Canonical: O59010 (Residues: 1-419; Coverage: 99%)
Gene name: PH1295
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

1 bound ligand:
Ligand 6OU 3 x 6OU
1 modified residue:
Ligand FME 3 x FME

Experiments and Validation Details

Entry percentile scores
Resolution: 3.66Å
Relevant EMDB volumes: EMD-21991
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression.
Ryan et al. (2021)
5 more

1 mention without citation

Structure Reveals Homology in Elevator Transporters.
Trebesch et al. (2023)