› 6x2j

Electron Microscopy
3Å resolution

Structure of human TRPA1 in complex with agonist GNE551

Released:
DOI: 10.2210/pdb6x2j/pdb
PDB entry 6x2j coloured by chain, front view.
PDB entry 6x2j coloured by chain, side view.
PDB entry 6x2j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.
Liu C, Reese R, Vu S, Rougé L, Shields SD, Kakiuchi-Kiyota S, Chen H, Johnson K, Shi YP, Chernov-Rogan T, Greiner DMZ, Kohli PB, Hackos D, Brillantes B, Tam C, Li T, Wang J, Safina B, Magnuson S, Volgraf M, Payandeh J, Zheng J, Rohou A, Chen J
Neuron 109 273-284.e4 (2021)
PMID: 33152265
Related structures: EMD-22009

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily A member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 631 amino acids
Theoretical weight: 72.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75762 (Residues: 448-1078; Coverage: 56%)
Gene names: ANKTM1, TRPA1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ULJ 4 x ULJ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-22009
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
8 more

6 mentions without citation

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
5 more