› 6x8p

X-ray diffraction
2.27Å resolution

Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein NPND peptide

Released:
DOI: 10.2210/pdb6x8p/pdb
Model geometry
Fit model/data
PDB entry 6x8p coloured by chain, front view.
PDB entry 6x8p coloured by chain, side view.
PDB entry 6x8p coloured by chain, top view.
Source organisms:
Primary publication:
Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11.
Kucharska I, Thai E, Srivastava A, Rubinstein JL, Pomès R, Julien JP
OpenAccess logo Elife 9 (2020)
PMID: 33253113

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279865 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
3D11 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 22.63 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
3D11 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 23.99 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Circumsporozoite protein Chain: P

Ligands and Environments

1 bound ligand:
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS-II BEAMLINE 17-ID-1
Spacegroup: P3221
Unit cell:
a: 59.859Å b: 59.859Å c: 235.005Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.166 0.222
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein.
Wahl et al. (2022)
1 more

1 mention without citation

Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11.
Kucharska et al. (2020)