› 6xaf

X-ray diffraction
1.97Å resolution

1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H

Released:
DOI: 10.2210/pdb6xaf/pdb
PDB entry 6xaf coloured by chain, front view.
PDB entry 6xaf coloured by chain, side view.
PDB entry 6xaf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Hoang QQ, Liao J, Huang X, Park Y, Wu CX

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177795 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat serine/threonine-protein kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 206 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5S007 (Residues: 1329-1520; Coverage: 8%)
Gene names: LRRK2, PARK8
Sequence domains: Ras of Complex, Roc, domain of DAPkinase

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand GDP 2 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 44.497Å b: 101.785Å c: 44.527Å
α: 90° β: 101.38° γ: 90°
R-values:
R R work R free
0.183 0.18 0.221
Expression system: Escherichia coli BL21(DE3)

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