6xc9

X-ray diffraction
2.4Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-208061 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
Ig-like domain-containing protein Chains: A, F
Molecule details ›
Chains: A, F
Length: 193 amino acids
Theoretical weight: 21.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q30069 (Residues: 1-184; Coverage: 81%)
Gene name: HLA-DQA1
Sequence domains:
Ig-like domain-containing protein Chains: C, H
Molecule details ›
Chains: C, H
Length: 230 amino acids
Theoretical weight: 26.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O19707 (Residues: 1-192; Coverage: 84%)
Gene name: HLA-DQB1
Sequence domains:
T-CELL-RECEPTOR, A3.10-alpha chain Chains: D, I
Molecule details ›
Chains: D, I
Length: 208 amino acids
Theoretical weight: 23.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
T-CELL-RECEPTOR, A3.10-beta chain Chains: E, J
Molecule details ›
Chains: E, J
Length: 245 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, FUC
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 65.993Å b: 114.79Å c: 153.926Å
α: 90° β: 90.066° γ: 90°
R-values:
R R work R free
0.186 0.184 0.219
Expression systems:
  • Trichoplusia ni
  • Escherichia coli BL21(DE3)
  • Escherichia coli BL21