› 6xcl

X-ray diffraction
2.7Å resolution

Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex.

Released:
DOI: 10.2210/pdb6xcl/pdb
PDB entry 6xcl coloured by chain, front view.
PDB entry 6xcl coloured by chain, side view.
PDB entry 6xcl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.
Miron CE, van Staalduinen L, Rangaswamy AM, Chen M, Liang Y, Jia Z, Mergny JL, Petitjean A
Angew Chem Int Ed Engl 60 2500-2507 (2021)
PMID: 33090592

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120929 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 22 nucleotides
Theoretical weight: 6.98 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand V4A 3 x V4A
Ligand EDO 2 x EDO
Ligand K 5 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: P3
Unit cell:
a: 64.03Å b: 64.03Å c: 42.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.191 0.243
Expression system: Not provided

Quick links

Citations

1 review citation

Designing Artificial Metalloenzymes by Tuning of the Environment beyond the Primary Coordination Sphere.
Van Stappen et al. (2022)
4 other articles

1 mention without citation

Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures.
Criscuolo et al. (2022)