› 6xdc

Electron Microscopy
2.9Å resolution

Cryo-EM structure of SARS-CoV-2 ORF3a

Released:
DOI: 10.2210/pdb6xdc/pdb
PDB entry 6xdc coloured by chain, front view.
PDB entry 6xdc coloured by chain, side view.
PDB entry 6xdc coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.
Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG
bioRxiv (2021)
PMID: 32587976
Related structures: EMD-22136

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144983 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ORF3a protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 284 amino acids
Theoretical weight: 32.17 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0DTC3 (Residues: 1-275; Coverage: 100%)
Gene name: 3a
Sequence domains: Betacoronavirus viroporin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-22136
Expression system: Spodoptera frugiperda

Quick links

Citations

26 review citations

Structural biology of SARS-CoV-2 and implications for therapeutic development.
Yang et al. (2021)
25 more

65 mentions without citation

Structural insights into SARS-CoV-2 proteins.
Arya et al. (2021)
64 more