› 6xf3

X-ray diffraction
2.38Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 189 amino acids
Theoretical weight: 21.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand V5V 1 x V5V
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 33.82Å b: 78.11Å c: 132.212Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.208 0.26
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.
Garland et al. (2022)
12 more

1 mention without citation

The Many Ways to Deal with STING.
Coderch et al. (2023)