› 6xiy

X-ray diffraction
2.31Å resolution

Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to methyl 2-(acetylamino)-2-deoxy-1-thio-alpha-D-galactopyranose

Released:
DOI: 10.2210/pdb6xiy/pdb
PDB entry 6xiy coloured by chain, front view.
PDB entry 6xiy coloured by chain, side view.
PDB entry 6xiy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Gabba A, Bogucka A, Luz JG, Diniz A, Coelho H, Corzana F, Cañada FJ, Marcelo F, Murphy PV, Birrane G
Biochemistry 60 1327-1336 (2021)
PMID: 33724805

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184856 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain family 10 member A Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IUN9 (Residues: 181-308; Coverage: 41%)
Gene names: CLEC10A, CLECSF13, CLECSF14, HML
Sequence domains: Lectin C-type domain

Ligands and Environments

3 bound ligands:
Ligand Q3M 1 x Q3M
Ligand CA 3 x CA
Ligand CL 7 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P3121
Unit cell:
a: 52.289Å b: 52.289Å c: 113.274Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.162 0.202
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Insights into the Role of Sialylation in Cancer Metastasis, Immunity, and Therapeutic Opportunity.
Huang et al. (2022)
6 more