› 6xli

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210483 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
PT3 Fab Heavy Chain Chains: A, C, H
Molecule details ›
Chains: A, C, H
Length: 227 amino acids
Theoretical weight: 24.54 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
PT3 Fab Light Chain Chains: B, D, L
Molecule details ›
Chains: B, D, L
Length: 214 amino acids
Theoretical weight: 23.87 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Microtubule-associated protein tau Chains: E, F, P
Molecule details ›
Chains: E, F, P
Length: 14 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 527-539; Coverage: 2%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
1 modified residue:
Ligand TPO 6 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 126.24Å b: 83.66Å c: 166.87Å
α: 90° β: 92.5° γ: 90°
R-values:
R R work R free
0.186 0.186 0.213
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

GSK-3 and Tau: A Key Duet in Alzheimer's Disease.
Sayas et al. (2021)
1 more

1 mention without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)