6xp6

X-ray diffraction
2.4Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-208757 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (8 distinct):
HLA class II histocompatibility antigen, DQ alpha 1 chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 191 amino acids
Theoretical weight: 21.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01909 (Residues: 24-206; Coverage: 79%)
Gene name: HLA-DQA1
Sequence domains:
Ig-like domain-containing protein Chains: B, E
Molecule details ›
Chains: B, E
Length: 201 amino acids
Theoretical weight: 23.37 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q5Y7D3 (Residues: 33-224; Coverage: 84%)
Gene name: HLA-DQB1
Sequence domains:
3.C11 IgH Fab Chains: H, J
Molecule details ›
Chains: H, J
Length: 224 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
3.C11 IgK Fab Chains: G, I
Molecule details ›
Chains: G, I
Length: 214 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
DQ2-glia-a2 peptide Chains: C, F
Molecule details ›
Chains: C, F
Length: 26 amino acids
Theoretical weight: 2.44 KDa
Source organism: Triticum aestivum
Expression system: Trichoplusia ni

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer : NEW Components: NAG, BMA
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 91.847Å b: 143.047Å c: 170.153Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.212
Expression systems:
  • Trichoplusia ni
  • Escherichia coli