› 6xwz

X-ray diffraction
1.38Å resolution

Carbonic Anhydrase II-mediated hydrolysis of selenolester

Released:
DOI: 10.2210/pdb6xwz/pdb
Model geometry
Fit model/data
PDB entry 6xwz coloured by chain, front view.
PDB entry 6xwz coloured by chain, side view.
PDB entry 6xwz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selenolesterase enzyme activity of carbonic anhydrases
Angeli A, Carta F, Donnini S, Capperucci A, Ferraroni M, Tanini D, Supuran CT
Chem. Commun. (Camb.) (2020)

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: AAA
Molecule details ›
Chain: AAA
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand GOL 1 x GOL
Ligand GXE 1 x GXE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: P21
Unit cell:
a: 42.336Å b: 41.311Å c: 72.457Å
α: 90° β: 104.259° γ: 90°
R-values:
R R work R free
0.181 0.18 0.204
Expression system: Homo sapiens

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