› 6xy2

X-ray diffraction
3.05Å resolution

Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody

Released:
DOI: 10.2210/pdb6xy2/pdb
PDB entry 6xy2 coloured by chain, front view.
PDB entry 6xy2 coloured by chain, side view.
PDB entry 6xy2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody.
Gao H, Cai H, Liu J, Wang X, Zheng P, Devenport M, Xu T, Dou F, Liu Y, Zhou A
Cell Discov 6 79 (2020)
PMID: 33298884

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210687 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cytotoxic T-lymphocyte protein 4 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16410 (Residues: 38-160; Coverage: 65%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain
Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 247 amino acids
Theoretical weight: 26.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2221
Unit cell:
a: 163.862Å b: 254.478Å c: 66.935Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.249 0.292
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Mechanisms of Action and Limitations of Monoclonal Antibodies and Single Chain Fragment Variable (scFv) in the Treatment of Cancer.
Rodríguez-Nava et al. (2023)
3 other articles

2 mentions without citation

Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody.
Gao et al. (2020)
1 more