Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Influenza RNA-dependent RNA polymerase subunit PB1
- Protein A, Ig-binding domain
- Immunoglobulin/albumin-binding domain superfamily
- Influenza RNA-dependent RNA polymerase subunit PB2
- RNA-directed RNA polymerase, negative-strand RNA virus
- Influenza RNA-dependent RNA polymerase subunit PA
- Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
- Polymerase acidic protein
4 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-237366 (preferred)
Entry contents:
4 distinct polypeptide molecules
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (5 distinct):
Polymerase acidic protein
Molecule details ›
Chains: AP1, DP1
Length: 709 amino acids
Theoretical weight: 82.03 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Length: 709 amino acids
Theoretical weight: 82.03 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q9IMP5 (Residues: 1-709; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit
Molecule details ›
Chains: BP1, EP1
Length: 754 amino acids
Theoretical weight: 86.15 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Length: 754 amino acids
Theoretical weight: 86.15 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9IMP4 (Residues: 1-754; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2
Molecule details ›
Chains: CP1, FP1
Length: 920 amino acids
Theoretical weight: 104.27 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 920 amino acids
Theoretical weight: 104.27 KDa
Source organism: Influenza C virus (C/Johannesburg/1/66)
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9IMP3 (Residues: 1-774; Coverage: 100%)
Sequence domains:
- Influenza RNA polymerase PB2 N-terminal region
- Influenza RNA polymerase PB2 second domain
- Influenza RNA polymerase PB2 middle domain
- Influenza RNA polymerase PB2 helical domain
- Influenza RNA polymerase PB2 CAP binding domain
- Influenza RNA polymerase PB2 6th domain
- Influenza RNA polymerase PB2 C-terminal domain
