› 6y0f

X-ray diffraction
2.92Å resolution

Structure of human FAPalpha in complex with linagliptin

Released:
DOI: 10.2210/pdb6y0f/pdb
PDB entry 6y0f coloured by chain, front view.
PDB entry 6y0f coloured by chain, side view.
PDB entry 6y0f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nar H, Schnapp G, Schreiner P

Function and Biology Details

Reactions catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Hydrolysis of --Pro-|- and to a lesser extent --Ala-|- in oligopeptides.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171423 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Prolyl endopeptidase FAP Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 722 amino acids
Theoretical weight: 83.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: Q12884 (Residues: 36-757; Coverage: 95%)
Gene name: FAP
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 6 x NAG
Ligand 356 4 x 356
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 67.586Å b: 253.604Å c: 115.247Å
α: 90° β: 89.76° γ: 90°
R-values:
R R work R free
0.208 0.208 0.243
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017

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