› 6y2h

X-ray diffraction
2.15Å resolution

The crystal structure of human chloride intracellular channel protein 5

Released:
DOI: 10.2210/pdb6y2h/pdb
PDB entry 6y2h coloured by chain, front view.
PDB entry 6y2h coloured by chain, side view.
PDB entry 6y2h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conserved cysteine dioxidation enhances membrane interaction of human Cl- intracellular channel 5.
Ferofontov A, Vankova P, Man P, Giladi M, Haitin Y
FASEB J 34 9925-9940 (2020)
PMID: 32725932

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192732 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride intracellular channel protein 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 240 amino acids
Theoretical weight: 26.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZA1 (Residues: 175-410; Coverage: 58%)
Gene name: CLIC5
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SCN 13 x SCN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: C2
Unit cell:
a: 130.99Å b: 93.96Å c: 109.58Å
α: 90° β: 124.13° γ: 90°
R-values:
R R work R free
0.203 0.201 0.244
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Inflammasomes as regulators of mechano-immunity.
Bezbradica et al. (2024)
1 other article

2 mentions without citation

Bi-Allelic Novel Variants in CLIC5 Identified in a Cameroonian Multiplex Family with Non-Syndromic Hearing Impairment.
Wonkam-Tingang et al. (2020)
1 more