› 6y3c

X-ray diffraction
3.36Å resolution

Human COX-1 Crystal Structure

Released:
DOI: 10.2210/pdb6y3c/pdb
PDB entry 6y3c coloured by chain, front view.
PDB entry 6y3c coloured by chain, side view.
PDB entry 6y3c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human cyclooxygenase (hCOX)-1.
Miciaccia M, Belviso BD, Iaselli M, Cingolani G, Ferorelli S, Cappellari M, Loguercio Polosa P, Perrone MG, Caliandro R, Scilimati A
Sci Rep 11 4312 (2021)
PMID: 33619313

Function and Biology Details

Reaction catalysed: 
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149893 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Prostaglandin G/H synthase 1 Chain: A
Molecule details ›
Chain: A
Length: 576 amino acids
Theoretical weight: 66.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: P23219 (Residues: 24-599; Coverage: 100%)
Gene names: COX1, PTGS1
Sequence domains: Animal haem peroxidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand FLC 3 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6522
Unit cell:
a: 182.11Å b: 182.11Å c: 103.24Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.208 0.263
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017

Quick links

Citations

2 review citations

Structural basis for endoperoxide-forming oxygenases.
Mori et al. (2022)
1 more

34 mentions without citation

Acetylsalicylic Acid-Primus Inter Pares in Pharmacology.
Fijałkowski et al. (2022)
33 more