6y6s

X-ray diffraction
2.1Å resolution

Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8

Released:

Function and Biology Details

Reaction catalysed:
D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galactocerebrosidase Chain: A
Molecule details ›
Chain: A
Length: 654 amino acids
Theoretical weight: 74.6 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P54818 (Residues: 41-684; Coverage: 100%)
Gene name: Galc
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: R32
Unit cell:
a: 248.721Å b: 248.721Å c: 77.326Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.165 0.163 0.201
Expression system: Homo sapiens