Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Clathrin adaptor, mu subunit
- Adaptor protein complex, sigma subunit
- Mu homology domain
- Clathrin adaptor, mu subunit, conserved site
- AP complex, mu/sigma subunit
- Longin-like domain superfamily
- Beta-adaptin appendage, C-terminal subdomain
- Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
16 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
AP-2 complex (preferred)
PDBe Complex ID:
PDB-CPX-148381 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
AP-2 complex subunit alpha-2
Molecule details ›
Chain: A
Length: 628 amino acids
Theoretical weight: 70.31 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: Adaptin N terminal region
Length: 628 amino acids
Theoretical weight: 70.31 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
P18484 (Residues: 1-271, 272-622; Coverage: 66%)
Sequence domains: Adaptin N terminal region
AP-2 complex subunit beta
Molecule details ›
Chain: B
Length: 944 amino acids
Theoretical weight: 105.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 944 amino acids
Theoretical weight: 105.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P63010 (Residues: 1-937; Coverage: 100%)
Sequence domains:
AP-2 complex subunit mu
AP-2 complex subunit sigma
