Function and Biology Details
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Translational (tr)-type GTP-binding domain
- Initiation factor eIF2 gamma, C-terminal
- P-loop containing nucleoside triphosphate hydrolase
- Translation initiation factor IF2/IF5 domain
- Translation initiation factor 2, alpha subunit, C-terminal
- Translation initiation factor 2, alpha subunit, middle domain superfamily
- S1 domain
- Nucleic acid-binding, OB-fold
11 more domains
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
Eukaryotic translation initiation factor and RNA (preferred)
PDBe Complex ID:
PDB-CPX-138586 (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct RNA molecules
2 distinct RNA molecules
Macromolecules (5 distinct):
Eukaryotic translation initiation factor 2 subunit 2
Molecule details ›
Chain: s
Length: 333 amino acids
Theoretical weight: 38.45 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Domain found in IF2B/IF5
Length: 333 amino acids
Theoretical weight: 38.45 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P20042 (Residues: 1-333; Coverage: 100%)
Sequence domains: Domain found in IF2B/IF5
Eukaryotic translation initiation factor 2 subunit 1
Molecule details ›
Chain: r
Length: 315 amino acids
Theoretical weight: 36.16 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 315 amino acids
Theoretical weight: 36.16 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P05198 (Residues: 1-315; Coverage: 100%)
Sequence domains:
Eukaryotic translation initiation factor 2 subunit 3
Molecule details ›
Chain: t
Length: 472 amino acids
Theoretical weight: 51.18 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 472 amino acids
Theoretical weight: 51.18 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P41091 (Residues: 1-472; Coverage: 100%)
Sequence domains:
