6yd4

X-ray diffraction
1.7Å resolution

X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Canavanine-Amba

Released:

Function and Biology Details

Reaction catalysed:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140859 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Furin Chain: A
Molecule details ›
Chain: A
Length: 480 amino acids
Theoretical weight: 52.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09958 (Residues: 108-574; Coverage: 61%)
Gene names: FUR, FURIN, PACE, PCSK3
Sequence domains:
4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Canavanine-Amba Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 768 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P6522
Unit cell:
a: 131.685Å b: 131.685Å c: 155.499Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.153 0.169
Expression systems:
  • Homo sapiens
  • Not provided