› 6yjk

X-ray diffraction
2.37Å resolution

Structure of CYRI-B (FAM49B) from Rhincodon typus

Released:
DOI: 10.2210/pdb6yjk/pdb
Model geometry
Fit model/data
PDB entry 6yjk coloured by chain, front view.
PDB entry 6yjk coloured by chain, side view.
PDB entry 6yjk coloured by chain, top view.
Source organism: Rhincodon typus
Primary publication:
Structure of CYRI-B (FAM49B), a key regulator of cellular actin assembly.
Kaplan E, Stone R, Hume PJ, Greene NP, Koronakis V
OpenAccess logo Acta Crystallogr D Struct Biol 76 1015-1024 (2020)
PMID: 33021503

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-288752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CYRIA/CYRIB Rac1 binding domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.91 KDa
Source organism: Rhincodon typus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A7M4DUF3 (Residues: 1-325; Coverage: 100%)
Gene name: fam49b
Sequence domains: CYRIA/CYRIB Rac1 binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 39.81Å b: 72.23Å c: 107.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.277
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

The Application of CRISPR/Cas9 Technology for Cancer Immunotherapy: Current Status and Problems.
Wang et al. (2021)
6 other articles

1 mention without citation

Structure of CYRI-B (FAM49B), a key regulator of cellular actin assembly.
Kaplan et al. (2020)