› 6ypk

X-ray diffraction
1.79Å resolution

Crystal Structure of CK2alpha with GTP bound

Released:
DOI: 10.2210/pdb6ypk/pdb
PDB entry 6ypk coloured by chain, front view.
PDB entry 6ypk coloured by chain, side view.
PDB entry 6ypk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α.
Brear P, Ball D, Stott K, D'Arcy S, Hyvönen M
J Med Chem 63 12786-12798 (2020)
PMID: 33119282

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 328 amino acids
Theoretical weight: 39.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68400 (Residues: 2-329; Coverage: 84%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 57.7Å b: 45.37Å c: 63.49Å
α: 90° β: 110.98° γ: 90°
R-values:
R R work R free
0.181 0.179 0.21
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.
Atkinson et al. (2021)
4 other articles

3 mentions without citation

Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network.
Meller et al. (2023)
2 more