› 6yw8

Solution NMR

NMR solution structure of unbound recombinant human Nerve Growth Factor (rhNGF)

Released:
DOI: 10.2210/pdb6yw8/pdb
PDB entry 6yw8 coloured by chain, ensemble of 20 models, front view.
PDB entry 6yw8 coloured by chain, ensemble of 20 models, side view.
PDB entry 6yw8 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions.
Paoletti F, Merzel F, Cassetta A, Ogris I, Covaceuszach S, Grdadolnik J, Lamba D, Golič Grdadolnik S
Comput Struct Biotechnol J 19 2938-2949 (2021)
PMID: 34136093

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134067 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-nerve growth factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 13.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01138 (Residues: 122-239; Coverage: 53%)
Gene names: NGF, NGFB
Sequence domains: Nerve growth factor family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg2.
Paoletti et al. (2023)

2 mentions without citation

Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview.
Paoletti et al. (2021)
1 more