› 6yxy

Electron Microscopy
3.1Å resolution

State B of the Trypanosoma brucei mitoribosomal large subunit assembly intermediate

Released:
DOI: 10.2210/pdb6yxy/pdb
PDB entry 6yxy coloured by chain, front view.
PDB entry 6yxy coloured by chain, side view.
PDB entry 6yxy coloured by chain, top view.
Source organism: Trypanosoma brucei brucei
Primary publication:
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
Jaskolowski M, Ramrath DJF, Bieri P, Niemann M, Mattei S, Calderaro S, Leibundgut M, Horn EK, Boehringer D, Schneider A, Ban N
Mol Cell 79 629-644.e4 (2020)
PMID: 32679035
Related structures: EMD-11000

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 83-mer (preferred)
PDBe Complex ID:
PDB-CPX-104891 (preferred)
Entry contents:
80 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (81 distinct):
39S ribosomal protein L28, mitochondrial Chain: A1
Molecule details ›
Chain: A1
Length: 241 amino acids
Theoretical weight: 28.05 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q586A2 (Residues: 1-241; Coverage: 100%)
Gene names: Tb06.4F7.280, Tb927.6.4040
Large ribosomal subunit protein uL29m Chain: A2
Molecule details ›
Chain: A2
Length: 471 amino acids
Theoretical weight: 54.05 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38EM7 (Residues: 1-471; Coverage: 100%)
Gene name: Tb09.160.5240
Sequence domains: Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
Ribosomal protein L30 ferredoxin-like fold domain-containing protein Chain: A3
Molecule details ›
Chain: A3
Length: 218 amino acids
Theoretical weight: 25.22 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38ED8 (Residues: 1-218; Coverage: 100%)
Gene name: Tb09.211.0230
bL32m Chain: A5
Molecule details ›
Chain: A5
Length: 80 amino acids
Theoretical weight: 9.75 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q584F4 (Residues: 1-80; Coverage: 100%)
Gene names: Tb04.1H19.670, Tb927.4.2330
T. brucei spp.-specific protein Chain: A8
Molecule details ›
Chain: A8
Length: 181 amino acids
Theoretical weight: 21.66 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A1K1 (Residues: 1-181; Coverage: 100%)
Gene name: TbgDal_X2260
mL67 Chain: BA
Molecule details ›
Chain: BA
Length: 831 amino acids
Theoretical weight: 93.57 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q386Z1 (Residues: 1-831; Coverage: 100%)
Gene name: Tb11.55.0016
GTP-binding protein, putative Chain: EA
Molecule details ›
Chain: EA
Length: 576 amino acids
Theoretical weight: 65.53 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57TZ4 (Residues: 1-576; Coverage: 100%)
Gene names: Tb07.29D18.100, Tb927.7.1640
Sequence domains:
mL68 Chain: BB
Molecule details ›
Chain: BB
Length: 541 amino acids
Theoretical weight: 62.81 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A135 (Residues: 1-541; Coverage: 100%)
Gene name: TbgDal_X580
DEAD-box helicase, putative Chain: EB
Molecule details ›
Chain: EB
Length: 754 amino acids
Theoretical weight: 85.72 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A9G9 (Residues: 1-754; Coverage: 100%)
Gene name: TbgDal_XI14390
Sequence domains:
Pseudouridine synthase RsuA/RluA-like domain-containing protein Chain: EC
Molecule details ›
Chain: EC
Length: 406 amino acids
Theoretical weight: 46.37 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38FJ3 (Residues: 1-406; Coverage: 100%)
Gene name: Tb09.160.2000
Sequence domains: RNA pseudouridylate synthase
mL70 Chain: BD
Molecule details ›
Chain: BD
Length: 547 amino acids
Theoretical weight: 62.44 KDa
Source organism: Trypanosoma brucei brucei
TRUD domain-containing protein Chain: ED
Molecule details ›
Chain: ED
Length: 616 amino acids
Theoretical weight: 69.46 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q385G9 (Residues: 1-616; Coverage: 100%)
Gene name: Tb11.02.3800
Ribosomal protein L3 mitochondrial, putative Chain: AE
Molecule details ›
Chain: AE
Length: 473 amino acids
Theoretical weight: 55.07 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q580R4 (Residues: 1-473; Coverage: 100%)
Gene names: Tb03.5L5.850, Tb927.3.5610
Sequence domains: Ribosomal protein L3
mL71 Chain: BE
Molecule details ›
Chain: BE
Length: 449 amino acids
Theoretical weight: 50.31 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57WG1 (Residues: 1-449; Coverage: 100%)
Gene names: Tb07.28B13.610, Tb927.7.3460
tRNA/rRNA methyltransferase SpoU type domain-containing protein Chain: EE
Molecule details ›
Chain: EE
Length: 586 amino acids
Theoretical weight: 67.17 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38DC9 (Residues: 1-586; Coverage: 100%)
Gene name: Tb09.211.3800
Sequence domains: SpoU rRNA Methylase family
UNK Chain: UE
Molecule details ›
Chain: UE
Length: 33 amino acids
Theoretical weight: 2.83 KDa
Source organism: Trypanosoma brucei brucei
Large ribosomal subunit protein uL4m Chain: AF
Molecule details ›
Chain: AF
Length: 459 amino acids
Theoretical weight: 53.16 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A7A6 (Residues: 1-459; Coverage: 100%)
Gene name: TbgDal_XI6750
Sequence domains: Ribosomal protein L4/L1 family
Tetratricopeptide repeat Chain: BF
Molecule details ›
Chain: BF
Length: 426 amino acids
Theoretical weight: 49.41 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: A0A3L6LA84 (Residues: 1-426; Coverage: 100%)
Gene name: DPX39_060043600
tRNA/rRNA methyltransferase SpoU type domain-containing protein Chain: EF
Molecule details ›
Chain: EF
Length: 373 amino acids
Theoretical weight: 40.11 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZWD9 (Residues: 1-373; Coverage: 100%)
Gene name: TbgDal_VIII6660
Sequence domains: SpoU rRNA Methylase family
mt-LAF7 Chain: EG
Molecule details ›
Chain: EG
Length: 156 amino acids
Theoretical weight: 18.65 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q387S8 (Residues: 1-156; Coverage: 100%)
Gene name: Tb10.61.0430
mL74 Chain: BH
Molecule details ›
Chain: BH
Length: 349 amino acids
Theoretical weight: 39.77 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38AM5 (Residues: 1-349; Coverage: 100%)
Gene name: Tb10.6k15.3290
mt-LAF8 Chain: EH
Molecule details ›
Chain: EH
Length: 634 amino acids
Theoretical weight: 68.9 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57ZS6 (Residues: 1-634; Coverage: 100%)
Gene names: Tb05.1P6.140, Tb927.5.2070
Ribosomal protein L9 domain-containing protein Chain: AI
Molecule details ›
Chain: AI
Length: 263 amino acids
Theoretical weight: 30.73 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57UC5 (Residues: 1-263; Coverage: 100%)
Gene names: Tb05.6E7.50, Tb927.5.3410
Sequence domains: Ribosomal protein L9, N-terminal domain
Mitochondrial RNA binding complex 1 subunit Chain: BI
Molecule details ›
Chain: BI
Length: 342 amino acids
Theoretical weight: 39.77 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A108 (Residues: 1-342; Coverage: 100%)
Gene name: TbgDal_X310
MALSU1 Chain: EI
Molecule details ›
Chain: EI
Length: 349 amino acids
Theoretical weight: 39.55 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q584Y2 (Residues: 1-349; Coverage: 100%)
Gene names: Tb06.2N9.480, Tb927.6.3420
Sequence domains: Ribosomal silencing factor during starvation
UNK Chain: UI
Molecule details ›
Chain: UI
Length: 23 amino acids
Theoretical weight: 1.98 KDa
Source organism: Trypanosoma brucei brucei
Ribosomal protein S24/S35 mitochondrial conserved domain-containing protein Chain: BJ
Molecule details ›
Chain: BJ
Length: 333 amino acids
Theoretical weight: 39.64 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q383M2 (Residues: 1-333; Coverage: 100%)
Gene name: Tb11.01.2340
L0R8F8 Chain: EJ
Molecule details ›
Chain: EJ
Length: 116 amino acids
Theoretical weight: 13.44 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57UQ1 (Residues: 1-116; Coverage: 100%)
Gene names: Tb07.5F10.320, Tb927.7.4210
Large ribosomal subunit protein uL11m Chain: AK
Molecule details ›
Chain: AK
Length: 342 amino acids
Theoretical weight: 40.27 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q586R9 (Residues: 1-342; Coverage: 100%)
Gene names: 30M24.135, 30M24.210, Tb927.2.4740, Tb927.2.4890
Sequence domains:
J domain-containing protein Chain: BK
Molecule details ›
Chain: BK
Length: 386 amino acids
Theoretical weight: 43.75 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZQR6 (Residues: 1-386; Coverage: 100%)
Gene name: TbgDal_VI2240
Sequence domains: DnaJ domain
Acyl carrier protein Chains: EK, ER
Molecule details ›
Chains: EK, ER
Length: 148 amino acids
Theoretical weight: 16.55 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57WW9 (Residues: 1-148; Coverage: 100%)
Gene names: Tb03.27F10.580, Tb927.3.860
Sequence domains: Phosphopantetheine attachment site
UNK Chain: UK
Molecule details ›
Chain: UK
Length: 25 amino acids
Theoretical weight: 2.15 KDa
Source organism: Trypanosoma brucei brucei
mL78 Chain: BL
Molecule details ›
Chain: BL
Length: 312 amino acids
Theoretical weight: 35.1 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q389N4 (Residues: 1-312; Coverage: 100%)
Gene name: Tb10.26.1000
mt-LAF12 Chain: EL
Molecule details ›
Chain: EL
Length: 691 amino acids
Theoretical weight: 77.91 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZVC0 (Residues: 1-691; Coverage: 100%)
Gene name: TbgDal_VIII3060
UNK Chain: UL
Molecule details ›
Chain: UL
Length: 72 amino acids
Theoretical weight: 6.15 KDa
Source organism: Trypanosoma brucei brucei
G domain-containing protein Chain: EM
Molecule details ›
Chain: EM
Length: 451 amino acids
Theoretical weight: 50.42 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38E75 (Residues: 1-451; Coverage: 100%)
Gene name: Tb09.211.0810
Sequence domains: 50S ribosome-binding GTPase
UNK Chain: UM
Molecule details ›
Chain: UM
Length: 8 amino acids
Theoretical weight: 699 Da
Source organism: Trypanosoma brucei brucei
50S ribosomal protein L13, putative Chain: AN
Molecule details ›
Chain: AN
Length: 202 amino acids
Theoretical weight: 24.34 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q580D5 (Residues: 1-202; Coverage: 100%)
Gene names: Tb04.5E12.380, Tb927.4.1070
Sequence domains: Ribosomal protein L13
mL80 Chain: BN
Molecule details ›
Chain: BN
Length: 302 amino acids
Theoretical weight: 34.88 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZQF0 (Residues: 1-302; Coverage: 100%)
Gene name: TbgDal_VI1080
T. brucei spp.-specific protein Chain: EN
Molecule details ›
Chain: EN
Length: 731 amino acids
Theoretical weight: 82.11 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZPS0 (Residues: 1-731; Coverage: 100%)
Gene name: TbgDal_V5380
uL14m Chain: AO
Molecule details ›
Chain: AO
Length: 217 amino acids
Theoretical weight: 25.13 KDa
Source organism: Trypanosoma brucei brucei
mL81 Chain: BO
Molecule details ›
Chain: BO
Length: 262 amino acids
Theoretical weight: 29.28 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q385L5 (Residues: 1-262; Coverage: 100%)
Gene name: Tb11.02.3230
T. brucei spp.-specific protein Chains: EO, EP
Molecule details ›
Chains: EO, EP
Length: 319 amino acids
Theoretical weight: 34.62 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZMA6 (Residues: 1-319; Coverage: 100%)
Gene name: TbgDal_IV4790
Large ribosomal subunit protein uL15/eL18 domain-containing protein Chain: AP
Molecule details ›
Chain: AP
Length: 374 amino acids
Theoretical weight: 43.78 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57U68 (Residues: 1-374; Coverage: 100%)
Gene names: Tb05.6E7.1030, Tb927.5.3980
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Peptidyl-prolyl cis-trans isomerase Chain: BQ
Molecule details ›
Chain: BQ
Length: 231 amino acids
Theoretical weight: 25.58 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57WF8 (Residues: 1-231; Coverage: 100%)
Gene names: Tb07.28B13.640, Tb927.7.3430
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
EngB-type G domain-containing protein Chain: EQ
Molecule details ›
Chain: EQ
Length: 655 amino acids
Theoretical weight: 71.47 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q380Y8 (Residues: 1-655; Coverage: 100%)
Gene name: Tb11.01.8760
Sequence domains: 50S ribosome-binding GTPase
50S ribosomal protein L17, putative Chain: AR
Molecule details ›
Chain: AR
Length: 301 amino acids
Theoretical weight: 35.12 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57YI7 (Residues: 1-301; Coverage: 100%)
Gene names: Tb08.11J15.1100, Tb927.8.5860
Sequence domains: Ribosomal protein L17
mL84 Chain: BR
Molecule details ›
Chain: BR
Length: 205 amino acids
Theoretical weight: 24.77 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q586A6 (Residues: 1-205; Coverage: 100%)
Gene names: Tb06.4F7.230, Tb927.6.4080
mL85 Chain: BS
Molecule details ›
Chain: BS
Length: 198 amino acids
Theoretical weight: 22.66 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38FG8 (Residues: 1-198; Coverage: 100%)
Gene name: Tb09.160.2250
Fungal lipase-like domain-containing protein Chain: ES
Molecule details ›
Chain: ES
Length: 524 amino acids
Theoretical weight: 58.83 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: A0A3L6L1Y4 (Residues: 1-524; Coverage: 100%)
Gene name: DPX39_090084400
Sequence domains: Lipase (class 3)
bL19m Chain: AT
Molecule details ›
Chain: AT
Length: 144 amino acids
Theoretical weight: 16.93 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q4GZ98 (Residues: 1-144; Coverage: 100%)
Gene name: TB927.1.1210
mL86 Chain: BT
Molecule details ›
Chain: BT
Length: 191 amino acids
Theoretical weight: 22.38 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: A0A3L6L8W0 (Residues: 1-191; Coverage: 100%)
Gene name: DPX39_050048100
mt-LAF19 Chain: ET
Molecule details ›
Chain: ET
Length: 102 amino acids
Theoretical weight: 12.08 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q383S4 (Residues: 1-102; Coverage: 100%)
Gene name: Tb11.01.1810
Large ribosomal subunit protein bL20c Chain: AU
Molecule details ›
Chain: AU
Length: 213 amino acids
Theoretical weight: 24.39 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q383R2 (Residues: 1-213; Coverage: 100%)
Gene name: Tb11.01.1930
T. brucei spp.-specific protein Chain: BU
Molecule details ›
Chain: BU
Length: 185 amino acids
Theoretical weight: 22.34 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A7Z9 (Residues: 1-185; Coverage: 100%)
Gene name: TbgDal_XI9190
mt-LAF20 Chain: EU
Molecule details ›
Chain: EU
Length: 56 amino acids
Theoretical weight: 6.94 KDa
Source organism: Trypanosoma brucei brucei
Large ribosomal subunit protein bL21m Chain: AV
Molecule details ›
Chain: AV
Length: 188 amino acids
Theoretical weight: 20.9 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZT11 (Residues: 52-239; Coverage: 79%)
Gene name: TbgDal_VII4650
Sequence domains: Ribosomal prokaryotic L21 protein
mL88 Chain: BV
Molecule details ›
Chain: BV
Length: 190 amino acids
Theoretical weight: 22.26 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZUW3 (Residues: 1-190; Coverage: 100%)
Gene name: TbgDal_VIII1510
Large ribosomal subunit protein uL22c Chain: AW
Molecule details ›
Chain: AW
Length: 278 amino acids
Theoretical weight: 32.08 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZSI8 (Residues: 1-278; Coverage: 100%)
Gene name: TbgDal_VII3160
Sequence domains: Ribosomal protein L22p/L17e
mL89 Chain: BW
Molecule details ›
Chain: BW
Length: 188 amino acids
Theoretical weight: 22.21 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57WW5 (Residues: 1-188; Coverage: 100%)
Gene names: Tb03.27F10.650, Tb927.3.820
Large ribosomal subunit protein uL23m Chain: AX
Molecule details ›
Chain: AX
Length: 246 amino acids
Theoretical weight: 28.85 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q387G3 (Residues: 1-246; Coverage: 100%)
Gene name: Tb11.03.0260
LIM zinc-binding domain-containing protein Chain: BX
Molecule details ›
Chain: BX
Length: 190 amino acids
Theoretical weight: 22.12 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q585P1 (Residues: 1-190; Coverage: 100%)
Gene names: Tb06.28P18.570, Tb927.6.1700
Sequence domains: LIM domain
UNK Chain: UX
Molecule details ›
Chain: UX
Length: 180 amino acids
Theoretical weight: 15.34 KDa
Source organism: Trypanosoma brucei brucei
KOW domain-containing protein Chain: AY
Molecule details ›
Chain: AY
Length: 378 amino acids
Theoretical weight: 44 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZK52 (Residues: 1-378; Coverage: 100%)
Gene name: TbgDal_III1550
Peptidyl-prolyl cis-trans isomerase Chain: BZ
Molecule details ›
Chain: BZ
Length: 190 amino acids
Theoretical weight: 20.54 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q383Y4 (Residues: 1-190; Coverage: 100%)
Gene name: Tb11.01.1215
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
mL93 Chain: Ba
Molecule details ›
Chain: Ba
Length: 153 amino acids
Theoretical weight: 18.93 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A4T0 (Residues: 1-153; Coverage: 100%)
Gene name: TbgDal_X13710
Rhodanese domain-containing protein Chain: Bb
Molecule details ›
Chain: Bb
Length: 162 amino acids
Theoretical weight: 17.83 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q38EP7 (Residues: 1-162; Coverage: 100%)
Gene name: Tb09.160.5050
mL95 Chain: Bc
Molecule details ›
Chain: Bc
Length: 146 amino acids
Theoretical weight: 17.8 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q389K3 (Residues: 1-146; Coverage: 100%)
Gene name: Tb10.26.0585
mL41 Chain: Ae
Molecule details ›
Chain: Ae
Length: 197 amino acids
Theoretical weight: 22.61 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q383U6 (Residues: 1-197; Coverage: 100%)
Gene name: Tb11.01.1600
mL42 Chain: Af
Molecule details ›
Chain: Af
Length: 189 amino acids
Theoretical weight: 21.6 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q383S1 (Residues: 1-189; Coverage: 100%)
Gene name: Tb11.01.1840
mL98 Chain: Bf
Molecule details ›
Chain: Bf
Length: 113 amino acids
Theoretical weight: 12.97 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q388M2 (Residues: 1-113; Coverage: 100%)
Gene name: Tb10.61.3155
Large ribosomal subunit protein mL43 Chain: Ag
Molecule details ›
Chain: Ag
Length: 260 amino acids
Theoretical weight: 31.3 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q583E5 (Residues: 1-260; Coverage: 100%)
Gene names: Tb04.3I12.430, Tb927.4.4600
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
mL99 Chain: Bg
Molecule details ›
Chain: Bg
Length: 105 amino acids
Theoretical weight: 12.33 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q587H8 (Residues: 1-105; Coverage: 100%)
Gene names: 10C8.95, Tb927.2.2590
mL100 Chain: Bh
Molecule details ›
Chain: Bh
Length: 92 amino acids
Theoretical weight: 10.6 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: A0A3L6L2V1 (Residues: 1-92; Coverage: 100%)
Gene name: DPX39_090047800
mL101 Chain: Bi
Molecule details ›
Chain: Bi
Length: 245 amino acids
Theoretical weight: 28.46 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q4GZ80 (Residues: 1-245; Coverage: 100%)
Gene name: TB927.1.1390
mL49 Chain: Al
Molecule details ›
Chain: Al
Length: 218 amino acids
Theoretical weight: 24.5 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q57Z82 (Residues: 1-218; Coverage: 100%)
Gene names: Tb05.27M3.100, Tb927.5.3110
mL52 Chain: Ao
Molecule details ›
Chain: Ao
Length: 1520 amino acids
Theoretical weight: 167.69 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: Q385V2 (Residues: 1-1522; Coverage: 100%)
Gene name: Tb11.02.2250
mL53 Chain: Ap
Molecule details ›
Chain: Ap
Length: 309 amino acids
Theoretical weight: 35.66 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: A0A3L6L3K9 (Residues: 1-309; Coverage: 100%)
Gene names: DPX39_070039500, DPX39_070040000
T. brucei spp.-specific protein Chain: At
Molecule details ›
Chain: At
Length: 154 amino acids
Theoretical weight: 18.21 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: C9ZU82 (Residues: 42-195; Coverage: 79%)
Gene name: TbgDal_VII8230
mL64 Chain: Av
Molecule details ›
Chain: Av
Length: 242 amino acids
Theoretical weight: 28.55 KDa
Source organism: Trypanosoma brucei brucei
UniProt:
  • Canonical: D0A934 (Residues: 1-242; Coverage: 100%)
Gene name: TbgDal_XI13040
12S ribosomal RNA Chain: AA
Molecule details ›
Chain: AA
Length: 1176 nucleotides
Theoretical weight: 373.91 KDa
Sequence domains: Trypanosomatid mitochondrial large subunit ribosomal RNA

Ligands and Environments

8 bound ligands:
Ligand ZN 5 x ZN
Ligand MG 33 x MG
Ligand SPD 1 x SPD
Ligand GTP 3 x GTP
Ligand NA 2 x NA
Ligand ATP 1 x ATP
Ligand PM8 2 x PM8
Ligand NAD 1 x NAD
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-11000

Quick links

Citations

11 review citations

Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins.
Pecoraro et al. (2021)
10 more