› 6yy5

X-ray diffraction
2.72Å resolution

Crystal structure of the ferric enterobactin receptor (PfeA) in complex with TCV_L5

Released:
DOI: 10.2210/pdb6yy5/pdb
PDB entry 6yy5 coloured by chain, front view.
PDB entry 6yy5 coloured by chain, side view.
PDB entry 6yy5 coloured by chain, top view.
Source organism: Pseudomonas aeruginosa PAO1
Primary publication:
Hijacking of the Enterobactin Pathway by a Synthetic Catechol Vector Designed for Oxazolidinone Antibiotic Delivery in Pseudomonas aeruginosa.
Moynié L, Hoegy F, Milenkovic S, Munier M, Paulen A, Gasser V, Faucon AL, Zill N, Naismith JH, Ceccarelli M, Schalk IJ, Mislin GLA
ACS Infect Dis (2022)
PMID: 35881068

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferric enterobactin receptor Chain: AAA
Molecule details ›
Chain: AAA
Length: 724 amino acids
Theoretical weight: 78.74 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05098 (Residues: 26-746; Coverage: 100%)
Gene names: PA2688, pfeA
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand FE 1 x FE
Ligand QDQ 1 x QDQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21212
Unit cell:
a: 85.795Å b: 157.049Å c: 77.503Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.258
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Engineering Siderophore Biosynthesis and Regulation Pathways to Increase Diversity and Availability.
Puja et al. (2023)
2 other articles