6yyo

X-ray diffraction
1.5Å resolution

Structure of Cathepsin S in complex with Compound 1

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150576 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin S Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 225 amino acids
Theoretical weight: 25.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25774 (Residues: 113-331; Coverage: 70%)
Gene name: CTSS
Sequence domains: Papain family cysteine protease

Ligands and Environments

No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P4122
Unit cell:
a: 85.458Å b: 85.458Å c: 150.899Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.139 0.137 0.169
Expression system: Escherichia coli