6z0u

Electron Microscopy
2.9Å resolution

CryoEM structure of the Chikungunya virus nsP1 complex

Released:

Function and Biology Details

Reactions catalysed:
ATP + RNA(n) = diphosphate + RNA(n+1)
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
ADP-D-ribose 1''-phosphate + H(2)O = ADP-D-ribose + phosphate
NTP + H(2)O = NDP + phosphate
A 5'-triphospho-[mRNA] + H(2)O = a 5'-diphospho-[mRNA] + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
PDBe Complex ID:
PDB-CPX-185036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mRNA-capping enzyme nsP1 Chains: A, BA, C, DA, E, FA, G, HA, I, JA, K, LA, M, NA, O, PA, Q, RA, S, TA, V, VA, X, Z
Molecule details ›
Chains: A, BA, C, DA, E, FA, G, HA, I, JA, K, LA, M, NA, O, PA, Q, RA, S, TA, V, VA, X, Z
Length: 472 amino acids
Theoretical weight: 53.06 KDa
Source organism: Chikungunya virus strain S27-African prototype
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q8JUX6 (Residues: 1-472; Coverage: 19%)
Sequence domains: Viral methyltransferase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-11023
Expression system: Baculovirus expression vector pFastBac1-HM