› 6z0z

X-ray diffraction
2.5Å resolution

Human wtSTING in complex with 3',3'-c-(2'FdAMP-2'FdAMP)

Released:
DOI: 10.2210/pdb6z0z/pdb
PDB entry 6z0z coloured by chain, front view.
PDB entry 6z0z coloured by chain, side view.
PDB entry 6z0z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Smola M, Gutten O, Dejmek M, Kožíšek M, Evangelidis T, Tehrani ZA, Novotná B, Nencka R, Birkuš G, Rulíšek L, Boura E
Angew Chem Int Ed Engl 60 10172-10178 (2021)
PMID: 33616279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 140-343; Coverage: 54%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand M8T 1 x M8T
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P43212
Unit cell:
a: 67.174Å b: 67.174Å c: 136.047Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.227
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Nanodelivery of STING agonists against cancer and infectious diseases.
Zhou et al. (2022)
4 other articles

2 mentions without citation

The Many Ways to Deal with STING.
Coderch et al. (2023)
1 more