› 6z2g

X-ray diffraction
1.95Å resolution

Crystal structure of human NLRP9 PYD

Released:
DOI: 10.2210/pdb6z2g/pdb
PDB entry 6z2g coloured by chain, front view.
PDB entry 6z2g coloured by chain, side view.
PDB entry 6z2g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.
Marleaux M, Anand K, Latz E, Geyer M
FEBS Lett 594 2383-2395 (2020)
PMID: 32542665

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 9 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 11.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7RTR0 (Residues: 1-97; Coverage: 10%)
Gene names: NALP9, NLRP9, NOD6, PAN12
Sequence domains: PAAD/DAPIN/Pyrin domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P6522
Unit cell:
a: 33.33Å b: 33.33Å c: 311.091Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

ATP-Binding and Hydrolysis in Inflammasome Activation.
Sandall et al. (2020)
7 more