6z3g

X-ray diffraction
2.78Å resolution

Repulsive Guidance Molecule A (RGMA) in complex with Growth Differentiation Factor 5 (GDF5)

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-154938 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth/differentiation factor 5 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43026 (Residues: 387-501; Coverage: 24%)
Gene names: BMP14, CDMP1, GDF5
Sequence domains: Transforming growth factor beta like domain
Repulsive guidance molecule A Chain: B
Molecule details ›
Chain: B
Length: 106 amino acids
Theoretical weight: 11.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96B86 (Residues: 54-139; Coverage: 21%)
Gene names: RGM, RGMA
Sequence domains: Repulsive guidance molecule (RGM) N-terminus

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6222
Unit cell:
a: 97.65Å b: 97.65Å c: 99.82Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.234 0.288
Expression systems:
  • Escherichia coli
  • Homo sapiens