Function and Biology Details
Biochemical function:
Biological process:
- not assigned
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Hemojuvelin and Growth/differentiation factor 5 (preferred)
PDBe Complex ID:
PDB-CPX-154937 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth/differentiation factor 5
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transforming growth factor beta like domain
Length: 117 amino acids
Theoretical weight: 13.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P43026 (Residues: 387-501; Coverage: 24%)
Sequence domains: Transforming growth factor beta like domain
Hemojuvelin
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 12.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Repulsive guidance molecule (RGM) N-terminus
Length: 122 amino acids
Theoretical weight: 12.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q6ZVN8 (Residues: 36-145; Coverage: 28%)
Sequence domains: Repulsive guidance molecule (RGM) N-terminus
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I03
Spacegroup:
P6222
Expression systems:
- Escherichia coli
- Homo sapiens
