Function and Biology Details
Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Armadillo-type fold
- Nonsense-mediated mRNA decay factor SMG8-like
- FATC domain
- P-loop containing nucleoside triphosphate hydrolase
- Nonsense-mediated mRNA decay factor SMG9
- Nonsense-mediated mRNA decay factor SMG8
- Phosphatidylinositol 3/4-kinase, conserved site
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185492 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Serine/threonine-protein kinase SMG1
Molecule details ›
Nonsense-mediated mRNA decay factor SMG8
Nonsense-mediated mRNA decay factor SMG9
Molecule details ›
Chain: C
Length: 520 amino acids
Theoretical weight: 57.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Length: 520 amino acids
Theoretical weight: 57.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9H0W8 (Residues: 1-520; Coverage: 100%)
Regulator of nonsense transcripts 1
Molecule details ›
Chain: E
Length: 11 amino acids
Theoretical weight: 1.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: Q92900 (Residues: 1085-1095; Coverage: 1%)
