› 6z9x

X-ray diffraction
2.68Å resolution

Human Class I Major Histocompatibility Complex, A02 allele, presenting LLS (t-butyl)Y FGTPT

Released:
DOI: 10.2210/pdb6z9x/pdb
PDB entry 6z9x coloured by chain, front view.
PDB entry 6z9x coloured by chain, side view.
PDB entry 6z9x coloured by chain, top view.
Source organisms:
Primary publication:
Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells.
Man S, Redman JE, Cross DL, Cole DK, Can I, Davies B, Hashimdeen SS, Reid R, Llewellyn-Lacey S, Miners KL, Ladell K, Lissina A, Brown PE, Wooldridge L, Price DA, Rizkallah PJ
J Immunol 207 1009-1017 (2021)
PMID: 34321228

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-102976 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A140T913 (Residues: 25-300; Coverage: 80%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
LEU-LEU-SER-TUR-PHE-GLY-THR-PRO-THR Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.04 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 206.24Å b: 49.35Å c: 115.9Å
α: 90° β: 123.85° γ: 90°
R-values:
R R work R free
0.189 0.186 0.241
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 citations in other articles

Modified influenza M158-66 peptide vaccination induces non-relevant T-cells and may enhance pathology after challenge.
Lanfermeijer et al. (2023)

1 mention without citation

Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells.
Man et al. (2021)